La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Sue Tint - Sturdy fun

    Got this for my husband for his 40-something birthday, kind of as a gag. But, he absolutely loves it! Granted he can't ride it yet, since it keeps shooting out behind him when he tries to get on and pedal. But it sure is fun watching him try.

  • ellashiella - I like the 2014 better coz you can use your hand ...

    Im not impressed at all! I like the 2014 better coz you can use your hand gestures in selecting songs that you want. Let alone I don't like the challenges. I like the old version where you can dance whatever songs that you want and record yourself.

  • A. Wertheim - Avoid this product

    This is a sad joke. You can't leave anything to potential grandchildren unless they are named - no per stirpes choice for adult children who may have kids in the future. Financial institutions have better designations. This is only good for incredibly simple situations and for providing to pets. You can do better elsewhere, and the wills this provides can get you into potential tax trouble. Just lost $40.