La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • john person - Get some of your sanity back!

    My daughter saw this somewhere. I forget where she first got hooked on it. Actually, I'm the one they really caught. She has all of the past ones, so I guess I should have known this would make her Christmas list. I must say this usually brings our family together. Usually my daughter is fighting with her brothers about something or the other. Now, they all enjoy singing, shouting and fooling around together. My wife and I love to see them so happy together. Of course, when the game goes off, the peace goes with it. I can't say it's a fix all but with 3 children ages 12, 10 and 9 I'll take all the peace I can get.

  • Robert Conner - New Hawaii Five-O

    It was good, very good just like the Jack Lord version (1968) except for the quarrels between McGarrett and Danny (Danno) and Captain Lou Grover; Jack Lord's show was all harmony, but I do like the "Book'em, Danno!" at the end and the chemistry between Chin Ho and Kono!