La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Anomaleli - perfect for self defense

    smaller than I expected but this is good because it makes it more discreet. The sheath is not like one I have seen but I like it. It is plastic with a metal clip, but not cheaply made as far as I can see. It locks the knife into it without having to button anything, and comes out with a small jerk. PERFECT for self defense of course I hope I never have to use it but I am VERY pleased with this. Also came very sharp out of the box but can be made even sharper. This is great worth the price for anyone needing a self defense weapon.

  • Pushkar Ravi - Look no beyond !!!

    I have seen my friend using UAG case on his HTC One M7 and I really loved the case. I liked the muscular look of this case and was sure that I would help me on my iPhone 6 Plus with #bendgate BS.