La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
Xu Research Group - Dong Xu Research Group at Idaho State University, College of Pharmacy is working on innovative computational chemistry, biophysics, computer aided drug design (cadd), molecular dynamics, modeling and simulation in the areas of patient centered translational and clinical research.
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This is the last year I will utilize Intuit Payroll. This product cannot even be activated without giving Intuit a credit card number! This automatically enrolls you in auto-renew at an inflated price. They claim you can cancel, but it is not an easy to find option, if fact I will probably have to call support to cancel.
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