La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Gilead Sciences, Inc. - Gilead Sciences, Inc. is a research-based biopharmaceutical company focused on the discovery, development, and commercialization of innovative medicines.

  • http://www.gilead.com/about About Gilead Sciences, Inc. - Gilead Sciences, Inc. is actively advancing pharmaceuticals to address unmet medical needs for patients living with life-threatening diseases globally.
  • http://www.gilead.com/about/senior-management/senior-management Gilead Senior Management - Meet the Gilead Senior Leadership team and learn more about their roles within Gilead Sciences, Inc.
  • http://www.gilead.com/about/worldwide-operations Gilead Locations - Gilead has locations on six continents around the globe, making it one of the largest biopharmaceutical companies in the world.
  • http://www.gilead.com/about/business-conduct Business Code of Conduct | Gilead - Learn about Gilead's business code of conduct and read about Gilead's corporate compliance program.
  • http://www.gilead.com/about/business-partnerships Business Partnerships | Gilead - Contact the Corporate Development department for more information about business and corporate development opportunities.
  • http://www.gilead.com/about/corporate-history-timeline Gilead Corporate History Timeline - Read about significant events throughout Gilead's history, from its founding in 1987 to present day.
  • http://www.gilead.com/medicines/consumer-product-safety-improvement-act Consumer Product Safety Improvement Act - Access general conformity certificates for Gilead products issued under the Consumer Product Safety Improvement Act.
  • http://www.gilead.com/medicines/product-approval-timeline Gilead FDA Approval Timeline - See the Gilead FDA approval timeline for products from Gilead's founding in 1987 until present day.
  • http://www.gilead.com/research Research | Gilead - Learn about Gilead's research to advance therapeutics, including investigational pipeline products and clinical trials.
  • http://www.gilead.com/research/pipeline Gilead Pipeline - Gilead pipeline therapeutics demonstrate potential to advance the treatment of life-threatening disease, including liver disease, oncology, and HIV pipeline products.
  • http://www.gilead.com/research/investigator-sponsored Investigator Sponsored Research (ISR) | Gilead - To apply for support for investigator sponsored research, review the submission process and apply online.
  • http://www.gilead.com/responsibility/us-patient-access Gilead Patient Assistance - Find Gilead patient assistance programs that help make Gilead therapies accessible and affordable to patients in the United States.
  • http://www.gilead.com/responsibility/developing-world-access Developing World Access | Gilead - Gilead continuously works to increase developing world access to its medicines for HIV/AIDS, viral hepatitis and visceral leishmaniasis.
  • http://www.gilead.com/responsibility/policy-perspectives Gilead Policy Perspectives - Find position papers reflecting Gilead Sciences; perspective on key issues related to our mission to discover, develop and commercialize innovative medicines.
  • http://www.gilead.com/responsibility/gilead-foundation The Gilead Foundation - The Gilead Foundation is a non-profit organization that seeks to improve the health and well-being of underserved communities around the world.
  • http://www.gilead.com/news Gilead News - Find the latest Gilead Sciences, Inc. news, including corporate press releases, events, media fact sheets and more.
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  • Jim Bond - Comey's Reasoning

    This book makes sense of the FBI Director's decision not to recommend indictment of Hillary Clinton. Though I don't like unnamed sources there is a strong ring of truth in what Klein writes. I highly recommend this read.

  • Kaity - Not too bad

    They aren't quality stories. I reccomend this book to kids 6 and under. Some of the stories don't make sense.

  • Felonis E. Anderson - bottle half full

    so very little in the bottle, seems like the bottle would have been full it was not, did not complete the work to my car

  • Jaihawk - Another waste of 2 hours

    Another movie out of hollywood's movie mill. It seems these days it's all about entertaining you through constant action sequences without any real story to tell or having any real substance. There is no real connection to any of the cliché sidekick characters - a bow wielding female, axe wielding maniac, knife throwing stealthy dude, etc. Yawn. They try their best to take the super out of supernatural affirming mythological creatures (you know, the cool stuff they can do in movies) as mere myth, including any obvious hints Hercules may actually be the son of Zeus, and force you to sit through most of the movie watching 'been there done that' mele battles between armies controlled by the cliché (deceiving) evil king. The most uninteresting Hercules/movie yet.