La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    City: -122.3933 California, United States

  • D. Hamilton - Think twice before buying this camera!

    I am very disappointed with my purchase of the GoPro Hero 3 Black! After all the marketing I had seen on this camera, I couldn't wait to get one and was very excited to try it out. From the start there were numerous malfunctions and I am returning the camera for a refund. The problems I experienced are listed below.

  • Gatsby - Disappointing

    I really wanted to like this film, but just couldn't. It's a bland movie that doesn't work. While there are a couple of clever moments, overall the movie is boring and the characters uninteresting. Clearly an unnecessary re-make.

  • Jay Jay - Truly forbidden love

    PNR is one of my favorite genre and when I heard that this author was doing a PNR book I couldn't wait to read.

  • yancando - Less than thrilling

    I was expecting a psychological thriller but instead got people facing middle aged crisis. If I were a fan of romance novels, I would have liked it more. I'm never too fond of books that hop back and forth in the timeline like this one did. Not a bad story, just not the one for me.