La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Emily Conway - Gorgeous color

    I wanted to dye the ends of my hair, and since I have used splat before, I decided to go back to their products. I have never tried this color before, but decided to give it a shot. I was expecting a more bluish green, like what it looks like on the box, but the result was a gorgeous foresty dark green color that I absolutely loved. The color does wash out rather quickly (after 3 or 4 washes it fades), but even faded it looks pretty nice. (leave the dye in for over an hour for best results) I would strongly recommend this brand to anyone who wants vibrant hair color. But keep in mind, it is VERY messy and it WILL stain anything it touches.

  • kevin P thomas - Very Disappointed

    Unfortunately, if it seems too good to be true, it usually is. No exception here!!! The claim is you need no oil and nothing sticks. Well the first test was scrambled eggs, what happened they stuck to the pan.