La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Valannin - If only Heracles had such power!

    If there is one cable I would whole-heartedly trust to my Chimera-hunting needs, this would be the cable. No other cable has the tensile strength to properly and efficiently garrote a lycanthrope, asphyxiate an Esquilax or even gag a mermaid. Last week, using my trusty AudioQuest K2 (retrofitted with lead weights, bright orange latex paint and a generous coating of crushed glass stolen from the window of an abandoned church at midnight), I managed to snuff 3 golden unicorns in swift succession!

  • Kindle Customer - A good Hot Plate

    I have been using this Hot Plate for several months for chemical experiments where the temperature must be closely held to a certian value for hours at a time. The thermistatically controlled switch inside the Hot Plate seems to do this quite well.

  • lulu64 - Seems Like a First Rate Product

    I have to give this 5 stars simple because of the quality and function. If my dog hadn't been spooked by it (likely due to my10 year old shooting balls at him until I found out !) Otherwise, I think it would have been a hit in our household. Balls shoot with impressive velocity and it feels like a very durable machine. Love that you can use it plugged in OR charge it to allow more flexibility. It is packaged beautifully and am so bummed my dog never warmed up to it !!