La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • KoJones - Good price, but greasy.

    I purchased this product with the hope of finding a less-expensive alternative to MoroccanOil, but there is really no substitute so far. The oil is packaged well, arrived very promptly and is a great price, but the aroma is of a slightly rancid sandalwood and the oil is not absorbed easily. It left my hair limp and greasy and was not pleasant smelling. I'll save it for using in a pinch, but wouldn't suggest it for thick, coarse, curly Mediterranean hair.

  • PJDour - NRS Pilot Knofe

    Recently bought the NRS pilot knife for a week long kayak camping trip. I like the secure attachment to my PFD, but the nicest feature was the quick and sure release. It's somewhat "spring loaded" using the clips that secure it to the sheath. The blunt/flat point ensures no accidental punctures, and the formed semi-circle cutter makes fast cutting of ropes a snap. The quick release mechanism also locks the knife back in with a snap - if it does not snap, it's not in. Again, something almost foolproof, which is nice if you are reacting to an issue on the water. Great overall blade. I also ordered the Gerber Rivermate at the same time, as I have beena Gerber fan fr 40+ years, but the NRS Pilot wins my vote as the knife to carry on the water.