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La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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The edge grind on my knife was consistent and the tip was nice and straight. I put about a 1/4 of a cotton ball down in the base of the sheath and it eliminated the rattle. It is lightweight, but sturdy - I am only using it as a back-up defense, not as an every day carry knife and in that regard it is well designed and well executed by Gerber. If I was looking for an all purpose knife, which this is not, or a survival/bushcraft type knife, which this is not, I might be disappointed, but I am not. Right tool for the right job only, not a jack-of-all-trades blade. Made in USA at under $30, 420HC is a good choice for this application.
This was a great read. Their are some mistakes here and there as you find with a new author but the story was good and the editing acceptable. I will buy the next book in the series when it comes out.