La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Gregory S. Kellen - 2016 Jeep Cherokee Trailhawk...Great Vehicle

    Bought a 2016 Jeep Cherokee Trailhawk in early Spring of this year. Traded in a Jeep Wrangler for the Trailhawk and although we loved the Wrangler for it's rugged good looks and summertime topless fun, the Jeep Cherokee Trailhawk is a dream luxury 4 wheel drive. We have driven it to Colorado, Wisconsin and Vermont and it drives like a dream. Reliable, well built, great looks and loaded with modern day features. We love our Trailhawk now bring on Winter and lots of snow.

  • John G. Frykman - Great product but no excuse for charging extra for a cord!

    I bought this because a new counter top and under mounted sink reduced the distance between the sink drain and the wall opening for the drain. This disposal gave me an additional inch to work with, and although it barely worked, it DID work. That inch was critical. The good part was that I junked a working disposal that was under powered and over loud. This 3/4 hp disposal is ultra quiet, and will grind anything a rational person would put in it with ease, and very, very quietly. I would have given it 4 stars, but there is really no excuse for not shipping it with a cord already attached. The vast majority of people have that kind of connection. The cost of a Chinese (that's where the disposal is manufactured) power cord would be pennies. This is an artificial way of pricing the machine that is almost fraudulent, as most people will have to plunk down $12 more to make it operable. Far cheaper disposals have the power cord attached. All my other kitchen appliances came with cords with the exception of the dishwasher, where electric codes sometimes dictate wiring via a nonmetallic cable, or armored cable, came with cords!