La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • can+did SPACE - Great Alternative Headphones

    This KSCAT product is my first wireless Bluetooth headphones with bone conduction technology. I read that Ludwig Van Beethoven, who suffered hearing loss, may have been one of the first people to develop a bone-conducting device to help him hear music. He attached a rod to his piano and then connected it to his head, so that it transmitted the vibration of his playing directly to his cochlea. Bone-conducting headphones are built around this same concept. I find the concept of this bone conducting headphones interesting. It transmits music through your bones directly to your inner ear, so you can still hear everything around you.

  • Kiran DS - Terrific book

    The Gruber's SAT Guide was recommended by a colleague of mine whose kid did very well in his/her SAT exam last year. I find this book to be extremely good, useful and informative. I have been reading through the pages and find that there is a lot of knowledge to gain from and the practice questions are giving me a real challenge. I highly recommend this book to anybody who is preparing for the SAT.

  • Ruben - I bought two of this and installed them in two ...

    I bought two of this and installed them in two of my cars. The first one is still working after 3 months, but the second one it started with noises from the engine and then completely stopped working. I contacted the seller and they're sending me a replacement.