La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Amanda Banks - High Times DESK calendar

    Well, first of all this calendar is good. It's filled with some funny and interisting facts and I like the quotes included. I thought this was going to be a standard wall calendar but when it arrived it was only a small, day by day flip calendar. Nothing wrong with that, just not what I expected.

  • Alice - Wide variety of humor

    This calendar is amusing with a wide variety of humor. This year is a slightly updated design, with a more modern and sleek look which is nice. They did away with the back pages, which is sad-- the quizzes and brainteasers were entertaining (though the lists for babysitters and what to buy on sale when were exceptionally lame). I would love to see them add separate entries for Saturday and Sunday.

  • Carlos A. Murillo - Very helpful book

    I am not a programmer. I have been reading other basic books to understand Visual Basic. That's all that you need to be able to understand the Advanced Visual Basic 2010 book.

  • granny - Fantastic!!

    In the middle of the night the pain in my hands woke me up. I reached down in bed and put my hands on the top of my earthing half sheet and within a very short period of time the pain was gone.