La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Home - North Downs Specialist Referrals (NDSR) is an internationally acknowledged centre of excellence for Specialist Veterinary Care, offering access to one of the largest groups of recognised Veterinary Specialists in the UK and Europe.

  • http://www.ndsr.co.uk/en-GB/specialist-referral-service Specialist Referral Service - The Specialist vets working at North Downs Specialist Referrals multi-disciplinary referral service provide the highest levels of care for dogs and cats referred to us by veterinary surgeons across the UK.

    Country: 162.13.77.11, Europe, GB

    City: -0.1224 , United Kingdom

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