La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • David K Falcon - worst software and really worse product I've ever used

    worst software and really worse product I've ever used. Virtually unworkable , slow, prone to locking, up bizarre malfunctions, failure of outside software, (Neat receipts, Firefox) are routine. Loaded with features You will neither want or need. It's also slow so be prepared to look at the spinning blue circle more than you have since 1995.

  • Snowplow - DON'T BUY! Labeled for sale only OUTSIDE THE U.S. and won't install!

    Product was labeled for sale only in (some non-US country, don't recall where now) and wouldn't install, so was essentially worthless. Neither Amazon nor the seller tech_direct would do anything about it. Won't buy software from either again.