La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Amazon Customer - Will use an abacus before I upgrade again!

    Peachtree Complete (5 user) was always relatively expensive to upgrade, but it was nevertheless worthwhile to do every 2 years. A few years ago, as our small business grew to employ around 25 people we purchased the Quantum version for many thousands of dollars. So far, so good..... Unfortunately, not long after we got Quantum, Sage changed their business model so that every year you would have to bleed financially to "upgrade" your software. And the upgrades are pitiful for what new they offer.

  • Margaret Schlaudecker - Wasn't What I Expected

    I read the reviews & thought this book would help my daughter. It didn't. She said it did not have practice tests, so she really didn't feel prepared. I will get a different one before she takes it again.

  • John B. - MOOV NOW - LoveIT!

    Received this little gem just before xmas - was surprised at how small and light it is, don't notice it at all on your wrist or ankle. Very cool interface and activity tracking, have used it for jogging, workouts and swimming. Love that it's waterproof, don't have to take it off in the shower. MOOV sent it priority mail to Australia, very reasonable cost and fast delivery. Thank you MOOV, a brilliant piece of design and engineering!