La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Collin - limited focus

    I love Rick Steves travel books- if I'm only going to be visiting the places that he reviews. With as many years as he has been compiling information on Italy, I would hope that his Italy books would include Sicily and Sardinia, but they do not. If you're sticking to the big tourist destinations, this book is just what you want.

  • K. Baines - So sad - its really bad.

    If I could give it zero stars I would. The first two in the series had be really excited for the third but I got to the 6th chapter and I was REALLY trying to read it to the end but couldn't. GOOD LAWD THIS IS JUST HORRIBLE!!! I mean when did she become a hip hop want to be? Must we read over and over again how hot this one is or that one is...WE KNOW THE QUADS ARE HOT. We know they are her pack but how many times do we have read how they look and that they all love her desperately and she loves them desperately.