La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Byard F. Edwards - Having trouble getting the update successfully installed?

    The price was right by downloading from Amazon. The Personal database repopulated using last years tax return without a hitch. However, when it came to updating the software, I was unable to do so. Yes the data base downloaded and the installation engine performed its duties until the end was near, then it reversed itself. To no avail, I logged on as "Administrator" (right click icon) and used virtual OS with Vista and XP (currently with W7 OS). I reloaded the software and did a "repair" run. Still no success. Well, perhaps the upgrade code is a little funky and seen as a virus? I turned off my Kaspersky and Superantispyware software and presto: successful upgrade. Online help did not help but I told them the solution to my problem for what's it worth.

  • Selena Morville - Worked great in the beginning

    Worked great in the beginning! Lost a little weight. However, I did feel my body become immune to them after two weeks. At that point, I needed to take it later in the day (rather than early in the morning like I had been) in order for it to get me through the day with energy.