La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • MMCoakley - I wanted to believe!

    I am sorry to say this product did nothing for me. I poured over the reviews before purchasing - I actually did this on a few occasions and then finally decided to bite the bullet. I wanted so badly to believe everything good that I read about this (I think psychologists call this "confirmation bias"!) but in the end I saw absolutely no change at all. The good news is that I didn't see any negative or bad side effects either.

  • Sunny - beware of year, otherwise great

    Be aware that when the book says "2008-2009", it refers to the first year of medical school that you would be applying to enter. So, it's what you would want if you begin applying in the summer of 2007. Otherwise, the book is very helpful, although I wish that it contained more information on the rank of the school.