La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • C. Logan - Work well

    I'm very happy with these. I like the look of the steel instead of the black as well. No issues with them lighting up. I hope to attach them to some fence posts so that they stick above them for fence lighting. Nice way to illuminate along the yard when letting the dog out at night. They aren't crazy super bright, about the same as most solar lights. Glad I got them.

  • K. Troger - Very new to the game

    These feel great when hit well and fun to claim the name of the ball... I recommend these and a good price, too...

  • Steven king - The wood handle on mine is beautiful, no sharp corners

    Wow ! What a beast ! I was a little concerned that accuracy would be compromised due to the heft but boy was I wrong . Clearing vines , briars , and trimming or shaping bushes with ease and accuracy. The wood handle on mine is beautiful , no sharp corners, feels great in the hand . Far superior to the stamped out sheet metal kind . Sure wish it came with a sheath of some sort. Got to protect this jewel from shed hazards .

  • Santiago - Where is the Code?

    I ordered this product as a gift and when we opened it, the box is supposed to come with a "My Caudalie"code which had been crossed out by a black marker. Off course this was not the reason why we bought the product but it does make me question the legitimacy of it. Why was it crossed out?