La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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Sorry, after being a customer of Bitdefender for 4 years I've decided to go with another product. Bitdefender has many problems and bugs that have existed for a long time without remediation. They claim to have excellent customer support, but as a current customer with over 15 unanswered tickets in the past year alone, I have to say their service is terrible, lousy, rotten; meaning their commitment to their customers non-existent. No follow-ups, no replies to queries about open status. If you go to their online forums, all you'll find are unhappy customers who don't get answers.
I used this product on my 2002 Toyota Sienna which has a lot of exterior vinyl. Using very sparingly as per instructions the small 1.5 oz bottle covered the exterior, and made a big improvement in appearance. Next year the verdict will be out on how long it lasts. Personally I wouldn't use this product inside the vehicle as the fumes are really bad. I'd use Armoral. If the product lasts as long as the manufacturer claims I would give a 5 star rating. If it lasts only one season it's too pricey.
This is my first such machine, so I don't have the ability to compare it to competitive models. The "most popular positive review" on Amazon does a fine job of describing its attributes, so I won't duplicate those points. I will comment on my observations of the negative comments in the reviews: Leaking - not a problem with the one I bought. Pressure - one reviewer found it to be too harsh on the low setting - I find it to be very gentle on that setting, in fact, so much so that I never use it there. Attachments - yes, there are more than there are spaces for but so what? I put a couple of them in a drawer so that they'll be available if others wear out, get broken, or lost (sounds crazy? certainly not - I have six grandchildren). No switch on the handle - I hold the wand in my right hand and turn the on/off switch with my left - not a big deal. I will admit that having no experience at first, I got the bathroom counter wet a couple of times. There is just a bit of a learning curve, so you can't forget that you are turning on a pump that will spray the area if you don't have the tip in your mouth or pointed down in the sink. Bottom line is that I like the product and especially at the price.