La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

WWFT - Nursing, Education and Health Promotion Services - Independent nursing practice, sexual health, vaccination training, nurse education and adult learning, health promotion and community development, working with new migrants and refugees, menopause nurse specialists, nurse consultancy and management of nursing businesses in New Zealand.

  • http://www.wons.org.nz/elearning/ WWFT eLearning - Online eLearning for Nursing and Health Education - WWFT E-learning provides an accessible format for learning. It can be done in your own time and tests are open book. WWFT ensures quality through NZQA registration as a training organisation.

    Country: 210.5.50.39, Oceania, NZ

    City: 174.7833 Auckland, New Zealand

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