La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • John Armstrong - Great read

    I wasn't sure what to expect but the author drew me in quickly. Built a few characters early on that became the focus of the story. I really enjoyed this but didn't expect too. That said, I am a Sci-Fi and Sci-Fantasy fan but its been a while I read something I enjoyed. I will be picking up more books by this author

  • Amazon Customer - Unsafe!

    I was curious about "It Works" products, so decided to do my own research. All it took was a little google searching to find a legal case in CA charging "It Works Company" guilty of having unsafe levels of chemicals including lead. Now, with a "warning label" they still sell the same unsafe levels of chemicals, but can cover themselves by "telling" consumers this. I will not be buying, using, or recommending this product. Be smart when ordering anything that seems "too good to be true". And to anyone who may give this to their children (as many reviews mention), please reconsider.