La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Ender42 - Great TV, awesome picture, Prime Day price (from BestBuy)

    Just picked this 55" up from Best Buy when they matched the Prime Day sale price. It arrived today and I just got it mounted to the wall. The TV is much lighter than my old LG Plasma (50"), and the old mount that I had worked great. The picture quality on this TV blows away the picture on my LG, which was 8 years old and needed to be replaced anyway.

  • J. Walker - Excellent book for experienced db and Access users

    I had years of experience using Access in earlier versions and even taught courses, but have done nothing with it in the last 10 or 12 years. Because of that I was recently asked to help out on a large market research project. I quickly ordered this book and found it tremendously helpful for getting back into the program. Obviously, the program has changed a great deal since I last looked at it, but this book is so clearly written it very quickly brings you up to speed when you have a solid understanding of what databases do and the theory behind them. I particularly appreciate that the author avoids the annoying habit found in other books of describing the commands in older versions and then trying to explain the new version of the old command. To me, that is simply a distraction and usually a source of confusion.